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Inflammatory bowel disorders (IBD) are characterized by cycles of chronic relapses and remissions, chronic inflammation of the intestinal mucosa and an abnormal gut micro-flora. Sufferers tend to be afflicted by symptoms of poor digestion including gas, bloating and abdominal pain. These disorders can involve food sensitivities to common allergens such as gluten, which is found in certain grains, and casein which is found in dairy products. Celiac Disease, a type of severe gluten intolerance, is believed to affect 1 in 200 people in the modernized world. It causes an immune response to gluten which leads to intestinal inflammation and results in a decreased ability of the body to absorb nutrients.
IBD Relief includes specialized digestive enzymes that help to prevent the intestinal inflammation related to food intolerances and chronic intestinal disorders. These include AN-peptidases which are a source of DPP-IV, which break down gluten and other problematic proteins. Anti-inflammatory and stress-relieving botanicals Boswellia serrata, ashwagandha, and ginger are also included in the formula, as well as vitamin D3 which is important for immune system regulation. The probiotic yeast Saccharomyces boulardii also helps to reduce inflammation in the gut and protect the bowel from pathogens by promoting healthy intestinal flora.
Those who have inflammatory bowel disorders such as Crohn’s, Celiac Disease or colitis will benefit from taking IBD Relief. IBD Relief provides an innovative and effective combination of ingredients to help those with food sensitivities and intestinal inflammation to manage the symptoms and prevent exacerbation of the condition.
Animal experiments have shown that Boswellia modulates some components of the immune system, thereby reducing inflammation. In clinical trials, promising results were obtained in UC patients using Boswellia. All parameters studied improved with Boswellia supplementation. Furthermore, 82% of the patients treated with Boswellia went into remission whereas only 75% of the patients receiving sulfasalazine (an anti-inflammatory drug used to treat UC) experienced a remission. Similar results have also been shown for patients with Crohn's disease. It is not surprising that according to the latest survey, 36% of German IBD patients surveyed use Boswellia as part of their treatment protocol.DPP IV for Inflammation & Auto-immunityOver-activation of the immune system during an infection can drive the immune system into a state of autoimmunity, which leads to cellular damage and chronic inflammation. Autoimmunity can be promoted through the inappropriate activation of the immune system by certain proteins in the diet.
This is the underlying mechanism behind celiac disease, where the immune system inappropriately targets the protein gluten. The problem can be aggravated by a lack of dipeptidyl peptidase IV (DPP-IV) enzyme activity in certain gastrointestinal conditions.DPP-IV is an enzyme whose activity is required to break down proteins linked to the exacerbation of conditions such as IBD and celiac disease. DPP IV promotes a normal immune response and is important for the modulation of immune messengers that regulate immunity and inflammation. Low DPP-IV levels result in the accumulation of undigested protein fragments, which are thought to elicit an immune response that can inflame the lining of the gastrointestinal tract. Supplementation with DPP-IV enzymes prevents the activation of the immune system by breaking down dietary proteins like gluten before they activate an immune response - a significant benefit for those suffering from autoimmune disorders like IBD or celiac disease.AN -PeptidesResearch has shown that prolyl endopeptidases (PEPs) also help to break down gluten, reducing the occurrence of gluten-induced intestinal inflammation.
Currently, the only treatment for celiac disease is life-long avoidance of wheat, rye, barley and other gluten-containing foods. IBD Relief includes PEPs derived from the fungus Aspergillus niger (AN-PEP). AN-PEP is superior to other gluten-reducing enzymes because it remains active over a wide pH range, and is not destroyed by stomach acidity. Not only does AN-PEP work at stomach's natural pH, but it has been shown to degrade gluten proteins 60 times faster than other enzymes commonly used.Vitamin D and autoimmune diseases The evidence linking vitamin D and the prevalence of autoimmune diseases continue to grow. There is clear evidence that vitamin D is needed for the proper functioning of the immune system and especially for the maintenance of self-tolerance. Vitamin D has been shown to inhibit the induction of auto-immune diseases such as systemic lupus erythematosus, type-1 diabetes, and IBD. The vitamin D receptor also appears to have a critical role in the control and response of the colon to chemical injury.Withania Somnifera for StressThere is significant psychological stress in dealing with any chronic disease. Chronic stress may lead to a breakdown in coping mechanisms and worsen the course of IBD. Withania Somnifera is well known for its ability to enhance the body's response to stress. This traditional ayurvedic herb can also help support the immune system and liver function.A Successful CombinationIBD Relief provides an innovative and effective combination of ingredients to help those with IBD or celiac disease to manage and prevent inflammation and exacerbation of the condition. The effectiveness of IBD Relief can be further enhanced if combined with additional Vitamin D3 supplementation as well as a complete probiotic supplement, like Clinical Biotics, to help normalize the intestinal flora.
ReferencesGeier, M., Butler, R., Howarth, G. Inflammatory bowel disease: Current insights into pathogenesis and new therapeutic options; probiotics, prebiotics, and synbiotics. International J of Food Microbiology, 115 (2007), pp1-11.Gupta I, Parihar A, Malhotra P, Singh GB, Lüdtke R, Safayhi H, Ammon HP.
Effects of Boswellia serrata gum resin in patients with ulcerative colitis. Eur J Med Res. 1997 Jan;2(1):37-43.Gerhardt H, Seifert F, Buvari P, Vogelsang H, Repges R. Therapy of active Crohn disease with Boswellia serrata extract H 15. Z Gastroenterol. 2001 Jan;39(1):11-7.Sedo A, Malik R. Dipeptidyl peptidase IV-like molecules: homologous proteins or homologous activities? Biochim Biophys Acta. 2001 Dec 17;1550(2):107-16. Review.Tiruppathi C, Miyamoto Y, Ganapathy V, Leibach FH. Genetic evidence for the role of DPP IV in intestinal hydrolysis and assimilation of prolyl peptides. Am J Physiol. 1993 Jul;265(1 Pt 1): G81-9.Stepniak, D., et al. Highly efficient gluten degradation with a newly identified prolyl endoprotease: implications for celiac disease. The American Physiological Society. [Online] http://www.the-aps.org/press/journal/06/13.htm 2006.Froicu M, Cantorna MT. Vitamin D and the vitamin D receptor are critical for control of the innate immune response to colonic injury. BMC Immunol. 2007 Mar 30;8:5.Goodhand J, Rampton D. Psychological stress and coping in IBD. Gut. 2008 Oct;57(10):1345-7.Archana R, Namasivayam A.Antistressor effect of Withania Somnifera. J Ethnopharmacol 1999 Jan; 64(1): 91-3
DISCUSSION: IBD Relief is traditionally used in Herbal medicine to help relieve digestive upset/disturbances including lack of appetite, nausea, digestive spasms, indigestion, dyspepsia and flatulent colic. IBD Relief contains digestive enzymes that help digest proteins and a probiotic that forms part of a natural healthy gut flora and helps reduce the risk of antibiotic-associated diarrhea.
|Serving size: 4 Capsules||Amount Per Serving|
|ANPEP™ [protease from A. niger & A. flavus var. oryzae]||13.64 mg/1,900 HUT*|
|Ginger (Zingiber officinale,10:1)||300 mg|
|Saccharomyces boulardii||1.33 x 1010 CFU†|
|Boswellia serrata (40% boswellic acids)||600 mg|
|Vitamin D3||25 mcg/1000 IU|
|Withania somnifera (10:1)||100 mg|
|Non-medicinal ingredients: microcrystalline cellulose, potato starch, corn starch, maltodextrin, dextrin, ascorbyl palmitate, sucrose, D-alpha-tocopherol, silicon dioxide, sodium stearyl fumarate. Capsule: hypromellose.
ADULT DOSAGE: Take 3 capsules daily or 2 capsules twice daily with meals of your choice, or as directed by a qualified health care practitioner.
CAUTION: Consult a health care practitioner prior to use if you have gastrointestinal lesions/ulcers, are taking anticoagulant agents, anti-inflammatory agents or other enzyme products, are having surgery, or if you have nausea, fever, vomiting, bloody diarrhea or severe abdominal pain. Consult a health care practitioner for prolonged use. Discontinue use and consult a health care practitioner if symptoms (e.g. digestive upset, diarrhea) occur, worsen, or persist beyond 3 days. Hypersensitivity/allergy has been known to occur in which case discontinue use. Consumption with alcohol, other drugs or natural health products with sedative properties is not recommended. Do not use if you have an immune-compromised condition (e.g. AIDS, lymphoma, patients undergoing long-term corticosteroid treatment), or if you are pregnant or breastfeeding.
AOR™ guarantees that all ingredients have been declared on the label. Contains no gluten, nuts, peanuts, sulphites, mustard, dairy, eggs, shellfish or any animal byproduct.
The information and product descriptions appearing on this website are for information purposes only, and are not intended to provide or replace medical advice to individuals from a qualified health care professional. Consult with your physician if you have any health concerns, and before initiating any new diet, exercise, supplement, or other lifestyle changes.
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